Peripheral blood cellular dynamics of Rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs.

Samples from healthy blood donors, newly diagnosed RA patients, and established RA patients that had an inadequate response to MTX and were about to start tumor necrosis factor inhibitors (TNFi) treatment were collected before and after 3 months treatment. We used in parallel a computational deconvolution approach based on RNA expression and flow cytometry to determine the relative cell-type frequencies We included 53 DMARD treatment naïve early RA patients, 37 individuals who previously did not responded to MTX treatment and started TNFi treatment, and 30 age matched healthy controls at two timepoints separated by approximately 3 months. Data was pooled into 10 groups into each cohort ***Submitter declares that European law does not allow the deposit of the raw data to GEO***