Genetic downregulation of Dnm2 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)

In this study, we performed RNA sequencing on tibialis anterior muscle of male mice. WT and Mtm1 deficient (Mtm1-/y) mice as well as on Dnm2+/- mice and on Mtm1-/y mice crossed with Dnm2+/- (Mtm1-/yDnm2+/-) were sequenced. A longitudinal follow up was established by sequencing all the genotypes at E18.5, 2w and 7w. The study is composed of 4 groups of mice: WT, Mtm1-/y, Dnm2+/- and Mtm1-/yDnm2+/-, for each age. Each group was composed from 2 to 5 replicates. The comparison of transcriptome profiles across different ages and different genotypes was assessed in this study.