PRISM Repurposing 19Q4 Dataset

The PRISM Repurposing release contains small molecule viability datasets generated using the Broad Repurposing Library and the PRISM multiplexed cell-line viability assay.<br>The primary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 4,518 compounds screened against 578 or 562 cell lines. <br>The secondary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 1,448 compounds screened against 489 cell lines in an 8-step, 4-fold dilution, starting from 10uM. Technical redos for 147 previously screened oncology compounds have been added as of 11/22/2019. This data is identified using a `screen_id` of "MTS010". It is recommended to use MTS010 when available. MTS010 was not included in the analysis for Corsello et al. 2019, DOI:10.1101/730119.<br>Data processing steps are described in the README files. Further descriptions of methods are available at https://doi.org/10.1101/730119.<br>PRISM重用途数据集（PRISM Repurposing）版本包含采用Broad重用途文库（Broad Repurposing Library）与PRISM多重细胞系活力检测法（PRISM multiplexed cell-line viability assay）生成的小分子活力数据集。 PRISM重用途主数据集包含针对4518种化合物，分别在578或562株细胞系中开展的混合细胞系化学扰动活力筛选结果。 PRISM重用途次级数据集包含针对1448种化合物，以10μM为起始浓度、经8步4倍梯度稀释后，在489株细胞系中开展的混合细胞系化学扰动活力筛选结果。截至2019年11月22日，新增了147种此前已完成筛选的肿瘤化合物的技术重复实验数据。该数据集通过筛选标识符（screen_id）为"MTS010"进行标识，建议在可用时优先采用MTS010数据集。需注意，MTS010未纳入Corsello等人2019年发表的分析中，原文DOI：10.1101/730119。 数据集的处理步骤详见README文件。相关方法的进一步说明可访问DOI：10.1101/730119获取。