Expression of IL-4 regulated genes in HRS malignant cells.

*Numbers in parentheses indicate the number of genes within the gene-set analyzed.IL-4-regulated genes were identified experimentally by Elo et al[35]; of the 21014 annotated genes in the U133 plus2 Affymetrix array platform, 640 were identified as being up-regulated and 484 down-regulated by IL4 in T cells. Genes that were up- or down-regulated in microdissected HRS malignant cells from HL biopsies relative to control GC-centrocytes were identified from the data of Brune et al[38]. Complete gene-lists are available in Data-File S2. For the determination of OR and statistical significance, equal sized gene-sets were compared by ranking probe-sets according to the magnitude of FC of the HRS cells, and selecting the top 640 or 484 unique genes.