Small RNA-seq data of chicken GCs

Poultry follicle development is a dynamically biological process, and temporally specific expression of large number of functional genes precisely regulate this process. In this study, we study miRNA expression profiles of the chicken follilcular granulosa cells from 10 developmental stages, including pre-hierarchical follicle (SWF, LWF, SYF and LYF), hierarchical follicle (F5, F4, F3, F2 and F1) and post-ovulatory follicle (POF). We identified the temporal expression profiles of miRNAs during follicle development and constructed the miRNA-mRNA targeted network. The expression profile of miRNA at 10 stages could be clearly divided into three stages: pre-hierarchical, preovulatory and post-ovulatory stage. Among them, miR-148a-3p, with the highest expression abundacnce at all stages, showed significant dynamic changes across development. Functional enrichment analysis showed that temporally expressed miRNA function variation during follicular development.