Machine Learning for Prediction of Glycemic Control in Diabetes Mellitus

This study aims to predict glycemic control status three years after diagnosis and document the most important factors for glycemic control in diabetes mellitus. The data belongs to the people living in Istanbul. We identified newly diagnosed diabetes mellitus patients in Istanbul Province in 2017. The criteria for having diabetes were a diabetes diagnosis (ICD-10 codes E10-E14) or prescription of antidiabetic medications (except metformin) or having an HbA1c over 6.5. In addition, all the diabetic patients were checked if they had initial serum creatinine, lipid profile, at least four HbA1c measurements (roughly once a year). The patients were divided into two groups according to their profile of HbA1c levels; under control (the last two HbA1c values are under 7) or uncontrolled.
id: Patient id no
HbA1c: Serum level at diagnosis (%)
Hba1c_change: %, (level at 1st year-level at diagnosis)
sex: 1: female, 2: male
age: years
LDL: mg/dL, level at diagnosis
Cholesterol: mg/dL, level at diagnosis
HDL: mg/dL, level at diagnosis
Creatinine: mg/dL, level at diagnosis
Triglyceride: mg/dL, level at diagnosis
infectious_diseases;Malign_neoplasms;Obesity;Thyroid_dis;neoplasms_unknown;anemia;vitamin_deficiency;lipoprotein_met_dis;hematologic_dis;endocrine_other;bipolar_affective_dis;depression;anxiety_dis;Other_mental_dis;neuropathies;diabetic_nueropathy;nervous_sys_dis;cataract;retinopathy;refraction_dis;impacted_cerumen;tinnitus_h93_1;eye_other;otitis_externa_h60;mastoid_h60_h95;hypertension_i10;ischemic_heart_dis;cardiomyopathies;cerebrovascular;other_circulatory;respiratory_sys;oral_dis;gastro_oes_reflux;dyspepsia;digestive_sys_dis;skin_dis;musculoskeletal_dis;nephropaties;kidney_failure;other_genitourinary;pregnancy;birth;ceserian_multiple;other_pregnancy: 1: present in the first year of diagnosis, 0: absent in the first year of diagnosis
digestive_drugs;antiobesity;other_digestive;hematologic_drugs;cardiovascular_drugs;lipid_modifying;dermatologic_drugs;gynecologic_drugs;sex_hormones;systemic_hormones;glucagon;calcium_homeostasis_drugs;antiinfectives;vaccines;antineoplastics;endocrin_drugs;immunostimulants;immunosupresants;musculosceletal_drugs;anesthetics;analgesics;antiepileptics;antiparkinson;antipsychotics;anxiolytics;pshycoanaleptics;other_nervous_drugs;antiparasitic;respiratory_sys_drugs;eye_ear_drugs;various_drugs: 1: prescribed in the first year of diagnosis, 0: not prescribed in the first year of diagnosis.
akarboz;dapagliflozin;eksenatid;gliklazid;glimepirid;glipizid;linagliptin;nateglinid;pioglitazon_hcl;repaglinide;saksagliptin;sitagliptin;vildagliptin: prescribed amount in the first year after diagnosis (gram/year)
insulin_aspart;insulin_detemir;insulin_glarjin;insulin_glusilin;insulin_lispro;insulin_nph;insulin_reguler: prescribed amount in the first year after diagnosis (1000IU/year)
metformin_hcl: prescribed amount in the first year after diagnosis (kg/year)
Glycemic_control: 0: Under control, 1: Poor control