DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

Alliance of Genome Resources2026-08-01 收录

DNA损伤修复

基因组稳定性

数据链接：

https://www.yeastgenome.org/dataset/GSE46260 数据链接链接失效反馈

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DNA replication is sensitive to damage in the template

53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR)

DNA损伤修复

断裂诱导复制(BIR)

Source data for ‘53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR)’

Figshare2024-10-06 更新20

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability [RNA-seq]

基因组稳定性

长非编码RNA功能机制

Thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome, but specific biological functions and biochemical mechanisms have been discovered for only about a dozen lncRNAs.

NIAID Data Ecosystem10

Dataset for: Interaction of replication protein A with two acidic peptides from human Bloom syndrome protein

蛋白质相互作用

DNA损伤修复

Bloom syndrome protein (BLM) is one of five human RecQ helicases which maintain genomic stability. Interaction of BLM with replication protein A (RPA) stimulates the DNA unwinding ability of BLM. The

WILEY2018-02-15 更新10

Active DNA demethylation promotes cell fate specification and the DNA damage response [RNA-Seq]

表观遗传调控

DNA损伤修复

Neurons harbor high levels of endogenous single strand DNA breaks (SSBs) that are targeted to neuronal enhancers and correlate with marks of DNA demethylation. To determine the source of SSBs at neuro

NIAID Data Ecosystem20

CDK12 prevents MYC-induced transcription-replication conflicts [ChIP-seq]

基因组稳定性

转录-复制冲突调控

In order to identify genes and pathways necessary to preserve genome integrity upon Myc over-expression, we conducted a large siRNA-based screen in isogenic lines. We discovered several genes that sup

NIAID Data Ecosystem10

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

资源简介：

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