Transcriptome profiles of liver from cirrhotic rat treated with nizatidine

Male rats received repeated low-dose diethylnitrosamine (DEN) to induce liver cirrhosis, and were treated with nizatidine to examine change of liver transcriptome and its association with liver cancer chemopreventive effect of nizatidine.雄性大鼠经反复给予低剂量二乙基亚硝胺（diethylnitrosamine, DEN）诱导肝硬化，随后予以尼扎替丁（nizatidine）干预，以探究肝脏转录组的变化及其与尼扎替丁肝癌化学预防作用的关联。