EHF is an essential regulator of mammary alveolar lineage differentiation and putative suppressor of breast tumorigenesis

The Ets homologous factor (Ehf) is highly expressed in the mammary gland in pregnancy and lactation. Mothers with Ehf deletion fail to lactate due to impaired lobuloalveolar development. ATACseq profiling of luminal mammary epithelial cells at late pregnancy (18.5dP) demonstrated that loss of Ehf results in significant chromatin remodelling. ATAC sequencing of luminal mammary epithelial cells (Ter119–CD31−CD45–CD24+CD29Lo) from mice with and without deletion of Ehf at late pregnancy (18.5 days pregnant)