Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome

Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is characterized by flares of sterile arthritis with neutrophil infiltrate and the overproduction of Interleukin (IL)-1β. The purpose of this study was to elucidate the potential role of neutrophil subsets and neutrophil extracellular traps (NETs) in the pathogenesis of PAPA. The transcriptome of PAPA normal-dense neutrophils, autologous LDGs, and healthy control normal-dense neutrophils was characterized using RNASeq. The transcriptome of a PAPA skin biopsy and a healthy control skin sample was elucidated using RNASeq. This dataset includes a total of 5 individual samples. This study sought to characterize PAPA normal-dense neutrophils, autologous LDGs, and healthy control normal-dense neutrophils and determine their transcriptomic profiles. We also wanted to characterize the transcriptomic profile of PAPA skin compared to a healthy control skin.