Global gene expression in human T cells with targeted disruption of TRAF6 or HOIP

We profiled gene expression in human CD4 T cells with CRISPR disruptions of TRAF6 or HOIP. The dataset captures transcriptional outputs linked to CBM-proximal ubiquitin signaling and MALT1 activity, enabling comparison of TCR- and TNFR-driven responses and providing a resource to study how distinct E3 ligases shape NF-?B–related programs. Overall design: Primary human CD4? T cells from four donors were edited by CRISPR–Cas9 to disrupt TRAF6 or HOIP (RNF31). Cells were activated via plate-bound TCR/CD28 costimulation for 48 h prior to RNA collection. ############################################################## Raw data (FASTQ) available on SRA (BioProject Accession PRJNA1277211). ##############################################################