Dados_Repositório.xlsxDados_Estudo água

<strong>Background and Aim</strong>: Water intake can modulate the autonomic nervous system of healthy individuals. However, its impact of water intake on the autonomic nervous system in patients with liver cirrhosis, with or without clinically significant portal hypertension, remains unclear. This study aimed to assess the effect of water intake on the cardiac vagal index and heart rate in patients with liver cirrhosis and evaluate the influence of clinically significant portal hypertension on these parameters. <strong>Methods</strong>: Thirty-seven patients with liver cirrhosis (mean age 64.14±8.36 years, Child–Pugh classes A and B) were enrolled. Clinically significant portal hypertension was defined according to Baveno VII criteria. The cardiac vagal index was measured using the four-second test at baseline and 10, 20, and 30 minutes after ingesting 500 mL of water. <strong>Results</strong>: A significant increase in the cardiac vagal index was observed at 10, 20, and 30 minutes post-water ingestion compared to baseline (1.24±0.17, 1.25±0.16, 1.25±0.16 vs 1.19±0.15, respectively; p=0.021, 0.022, 0.037). Concurrently, heart rate decreased significantly at these time points (76±14, 74±13, 73±13 vs 77±14, respectively; p=0.021, &lt;0.001, &lt;0.001). Similar increases in the cardiac vagal index (p=0.010 and p=0.076) and decreases in heart rate (p&lt;0.001 and p=0.631) were observed in patients with and without clinically significant portal hypertension, respectively. <strong>Conclusions</strong>: Patients with liver cirrhosis exhibited an increased cardiac vagal index and decreased heart rate following water ingestion. The presence of clinically significant portal hypertension did not significantly influence these physiological responses.