Bulgecin A: The key to a broad-spectrum inhibitor that targets lytic transglycosylases

NIAID Data Ecosystem2026-05-02 收录

抗感染药物开发

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Bulgecin A: The key to a broad-spectrum inhibitor that targets lytic transglycosylases

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2024-11-06

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

细菌毒力抑制

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Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused by Staphylococcus aureus. S. aureus is the

NIAID Data Ecosystem60

WZ3105 KINOMEscan

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药物靶点发现

The KINOMEscan assay platform is based on a competition binding assay that is run for a compound of interest against each of a panel of 317 to 456 kinases. The assay has three components: a kinase-tag

NIAID Data Ecosystem30

Biophysical Survey of Small-Molecule β‑Catenin Inhibitors: A Cautionary Tale

肿瘤药物靶点验证

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The canonical Wingless-related integration site signaling pathway plays a critical role in human physiology, and its dysregulation can lead to an array of diseases. β-Catenin is a multifunctional prot

Figshare2022-05-17 更新10

Predicted binding energy in kcal/mol of andrographolide, compound 3f, and acarbose against yeast and human α-glucosidase.

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计算结合能预测

Predicted binding energy in kcal/mol of andrographolide, compound 3f, and acarbose against yeast and human α-glucosidase.

NIAID Data Ecosystem40

VIM-2-2, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening

抗菌药物发现

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VIM-2-2, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening Descriptor: 2-(4-fluorophenyl)carbonylbenzoic acid, BETA-LACTAMASE, CHLORIDE I

Protein Data Bank Japan2024-01-10 更新20

Bulgecin A: The key to a broad-spectrum inhibitor that targets lytic transglycosylases

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