Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe<sub>2</sub>)<sub>3</sub>‑Mediated Reductive Cyclopropanation
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资源简介：
A P(NMe2)3-mediated reductive cyclopropanation reaction of α-keto esters or amides with isatin-derived alkenes has been developed, providing efficient and diastereoselective synthesis of highly functionalized spirocyclopropyl oxindoles bearing two all-carbon quaternary centers. This reaction also represents a complementary and nonmetal-involving protocol for the challenging cyclopropanation of electron-deficient alkenes.
创建时间：
2014-11-07
