Highly Enantioselective Three-Component Direct Mannich Reactions of Unfunctionalized Ketones Catalyzed by Bifunctional Organocatalysts
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Highly_Enantioselective_Three_Component_Direct_Mannich_Reactions_of_Unfunctionalized_Ketones_Catalyzed_by_Bifunctional_Organocatalysts/2447782
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资源简介：
A highly stereoselective three-component direct Mannich reaction between aromatic aldehydes, p-toluenesulfonamide, and unfunctionalized ketones was achieved through an enolate mechanism for the first time with a bifunctional quinidine thiourea catalyst. The corresponding N-tosylated β-aminoketones were obtained in high yields and excellent diastereo- and enantioselectivities (up to >99:1 dr and >99% ee).
创建时间：
2016-02-20
