Supplementary Material for: An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants

Background: Skin aging is a multifactorial phenomenon
which causes alterations in skin physiological functions and, most
visibly, phenotypic changes. In particular, during the aging process,
hyaluronic acid, collagen, and elastin fibers undergo structural and
functional changes. Aims: This study aimed to give an
insight into the photo-protective benefits and efficacy of an oral
liquid nutricosmeceutical containing collagen bioactive peptides and
antioxidants to counteract the signs of aging. Methods: A
double-blind, randomized, placebo-controlled clinical trial was
conducted by an independent esthetic clinic on 120 healthy volunteer
subjects for 90 days. Subjects were divided into 2 groups: 60 subjects
consumed 1 bottle (50 mL) of the nutricosmeceutical daily and the other
60 consumed 1 bottle (50 mL) of the placebo. Outcome measures were
related to skin elasticity (expressed as Young's elasticity modulus) and
skin architecture (histological analysis). In addition, the subjects
recruited in this study underwent observational assessments through
self-assessment questionnaires. Results and Conclusions: Overall, we demonstrated a significant increase in skin elasticity (+7.5%), p
≤ 0.001 and an improvement in skin texture after daily oral consumption
of the nutricosmeceutical. We also obtained a positive patient feedback
through the self-assessment questionnaires. Taken together these
results show that this nutricosmeceutical supplement may have
photo-protective effects and help improve skin health.