Comparison of incubation times, survival and clinical stage durations between non-immunized infected wt mice (A) or wt mice immunized either (B) directly with AdTA or AdhPrP or (C) after transduction into DCs derived from C57BL/6 or Tg650 mice.

aMice were primed and boosted twice as described in Material and Methods and inoculated IP with 0.5% 139A brain homogenate two weeks after the second immunization. Results are presented in days post infection (dpi)±SD. bMice received three injections of 5×105 DC as described in Material and Methods and were inoculated ip with 0.5% 139A brain homogenate one week after the second immunization. Results are presented in days post infection (dpi)±SD. cMann-Whitney Test; p significant compared to untreated mice: NS = non significant. dOne mouse survived longer than 300 dpi and no PrPres was detected by Western Blot in the spleen at time of sacrifice.