Role of ligand-dependent conformational modulation of TNPO3 HEAT-repeat solenoid in nuclear import

Starting coordinate and other relevant files used for simulation, along with 1-microsecond trajectory files for six systems: TNPO3-WT.tar.xz: Unbound TNPO3 receptor TNPO3-SR-1SEP.tar.xz: TNPO3 in complex with SR protein with phosphorylated SER201 TNPO3-SR-2SEP.tar.xz: TNPO3 in complex with SR protein with phosphorylated SER201 and SER207 TNPO3-SR-3SEP.tar.xz: TNPO3 in complex with SR protein with phosphorylated SER201, SER207 and SER209 TNPO3-RAN-GDP.tar.xz: TNPO3 in complex with RAN in GDP-bound state TNPO3-RAN-GTP.tar.xz: TNPO3 in complex with RAN in GTP-bound state Coordinates of representative structures from PMF-defined states (compact, minimum and extended) for four systems (TNPO3-WT, TNPO3-SR_3SEP, TNPO3-RAN_GDP and TNPO3-RAN_GTP): PMF_Representative-structure.tar.xz: