Crystal structure of the OkaE-M64A mutant with a-ketoglutarate and okaramine A

Crystal structure of the OkaE-M64A mutant with a-ketoglutarate and okaramine A Descriptor: (1Z,4R,12S,14S,17Z)-12-hydroxy-19,19-dimethyl-5-(2-methylbut-3-en-2-yl)-3,5,16,21-tetrazaheptacyclo[14.13.0.03,14.04,12.06,11.020,28.022,27]nonacosa-1(29),6,8,10,17,20(28),22,24,26-nonaene-2,15-dione, 2-OXOGLUTARIC ACID, COBALT (II) ION, ... Authors: Yu, J.J, Yan, W.P, Wang, X.Y. Deposit date: 2025-03-31 Release date: 2026-03-11 Last modified: 2026-04-08 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Structural and mechanistic insights into azetidine-associated alpha KG-NHFe enzyme OkaE with multifunctional catalysis. Nat Commun, 17, 2026