Human PDE5 catalytic core in complex with avanafil
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Human PDE5 catalytic core in complex with avanafil Descriptor: 4-[(3-chloranyl-4-methoxy-phenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimid ine-5-carboxamide, MAGNESIUM ION, SULFATE ION, ... Authors: Hsieh, C.M, Chan, N.L. Deposit date: 2019-10-28 Release date: 2020-09-02 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting alpha-Helix Backbone Oxygen by Halogen Bonding. J.Med.Chem., 63, 2020
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2019-10-28
