Demographic characteristics of the AD patients and the age-matched controls at baseline and follow-up.

Values are means±SD, except as noted otherwise. ap<0.001 vs Controls. Abbreviations: 1-year AD cohort, AD patients with approximately one year between baseline and follow-up lumbar puncture; 2-year AD cohort, AD patients with approximately two years between baseline and follow-up lumbar puncture; Controls, healthy controls followed for 4 years; APOE ε4 carrier, at least one apolipoprotein E ε4 allele; MMSE, Mini-Mental State Examination.