PROTECTiO_db_v1_0_0.tar.gz

Name: PROTECTiO_db_v1_0_0.tar.gz
Creator: Nakamae, Kazuki
Published: 2024-12-18T00:00:00+08:00

Figshare2024-12-18 更新2026-04-08 收录

基因编辑安全性

RNA脱靶

数据链接：

https://figshare.com/articles/dataset/PROTECTiO_db_v1_0_0_tar_gz/28053845/1 数据链接链接失效反馈

官方服务：

资源简介：

<pre>This is the complete PROTECTiO Database (version v1.0.0), providing Tissue-specific RNA off-target risk induced by CBEs.</pre>

提供机构：

Nakamae, Kazuki

创建时间：

2024-12-18

DataSheet_1_Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma.pdf

通用型CAR-T疗法

基因编辑安全性

Autologous T cells expressing the Chimeric Antigen Receptor (CAR) have been approved as advanced therapy medicinal products (ATMPs) against several hematological malignancies. However, the generation

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Cas12a base editors induce efficient and specific editing with low DNA damage response (DNA targeted sequencing)

CRISPR碱基编辑优化

基因编辑安全性

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Off-target sequencing for IL2RG gRNA in human cells

CRISPR脱靶检测

基因编辑安全性

Off-target sequencing for IL2RG gRNA in human cells.Includes: 1) GUIDE-seq in HEK293-Cas9 cells, and 2) rhAmpSeq in HEK293-Cas9 + CD34+ HSPCs.

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DNA Nicks Promote Efficient and Safe Targeted Gene Correction

靶向基因校正

基因编辑安全性

Targeted gene correction employs a site-specific DNA lesion to promote homologous recombination that eliminates mutation in a disease gene of interest. The double-strand break typically used to initia

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High-throughput imaging of CRISPR- and rAAV-induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells

基因编辑安全性

高通量筛选

CRISPR-Cas technology has revolutionized gene editing, but concerns remain due to its propensity for off-target interactions. This, combined with genotoxicity related to double-strand breaks more gene

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PROTECTiO_db_v1_0_0.tar.gz

资源简介：

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