Metabolic pathway of LDL, HDL and TG, including diseases

This pathway shows genetic disorders related to lipoprotein metabolism. Two plasmalipoproteins, LDL and HDL, and one plasma lipid, triglyceride (TG), play an important role in this pathway. Hydrophobic lipids and fat-soluble vitamins are normally transported to the site of their uptake by transporters called lipoproteins, and any deregulation of the plasma concentrations of these proteins can cause dyslipidemias. Disorders resulting from an enzyme deficiency are highlighted in pink. More details on the composition of the various lipoproteins in this pathway are visualised in [https://www.wikipathways.org/index.php/Pathway:WP3601]. This pathway was inspired by Chapter 43 of the book of Blau (ISBN 3642403360 (978-3642403361)).

本路径展示了与脂蛋白代谢相关的遗传性疾病。其中两种质膜脂蛋白，即低密度脂蛋白（LDL）和高密度脂蛋白（HDL），以及一种血浆脂质——甘油三酯（TG），在此途径中发挥着重要作用。疏水性脂质和脂溶性维生素通常由称为脂蛋白的转运蛋白运输至其摄取部位，而这些蛋白血浆浓度的任何失调均可能导致血脂异常。由于酶缺乏引起的疾病以粉红色突出显示。关于本途径中各种脂蛋白组成的更详细信息可通过[https://www.wikipathways.org/index.php/Pathway:WP3601]进行可视化。本途径灵感来源于Blau所著之书的第43章（ISBN 3642403360（978-3642403361））。