pedican

Pediatric cancer (PC), that is cancer occurring in children, is the leading cause of death among children worldwide, with an incidence of 175,000 per year. Elucidating the genetic abnormalities and underlying cellular mechanisms may provide less toxic curative treatments. Therefore, it is important to understand the pathology of pediatric cancer at the genetic, genomic and epigenetic level.儿童癌症（Pediatric cancer, PC），即发生于儿童群体的恶性肿瘤，是全球范围内儿童致死的首要病因，年新增病例达175000例。阐明其遗传异常与潜在细胞机制，有望开发出毒性更低的根治性治疗方案。因此，从遗传、基因组与表观遗传层面解析儿童癌症的病理特征，具有重要意义。

搜集汇总

背景与挑战

背景概述

Pedican是一个专注于儿童癌症的基因数据库，致力于整合全面的基因资源，包括文献数据、临床变异、基因表达谱和生物通路。它涵盖了735个人类基因和270种癌症类型，为研究儿童癌症的遗传和分子机制提供支持。