Transcriptomic analysis of rat reward circuits in offspring of cocaine seeking parent

Previous studies indicate that the increase vulnerability and/or reduce resistance to drug addiction in descendants may contingent on highly motivated drug seeking experience of parent. However, How the neuroplasticity of the offspring changes is still unclear. Here, we analysis the 2 states (naive, after self-administration) transcriptome of 7 Reward-related brain areas (OFC, mPFC, NAc, dStr, Hippo, BLA, VTA) in offspring of cocaine self-administration/cocaine yoke/saline administration rat to reveal the neuroplasticity changes pattern of reward-related brain areas in offspring.