Interrogating Disease Gene Function
收藏NIAID Data Ecosystem2026-05-02 收录
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资源简介：
Genes and genetic variants associated with human disease are continually being discovered, but validating their causative roles and mechanisms remains a significant challenge. CRISPR/Cas9 genome editing in model organisms like zebrafish can enable phenotypic characterization of founder generation (F0) knockouts, but these approaches are not amenable to high-throughput genetic screening due to high variability, cost, and low phenotype penetrance.
创建时间：
2024-06-12
