Human SARM1 TIR domain bound to compound 14
收藏Protein Data Bank Japan2026-04-29 更新2026-05-02 收录
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Human SARM1 TIR domain bound to compound 14 Descriptor: 1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-4-[(6P)-7-{[2-(dimethylamino)ethyl]amino}-6-(5-fluoro-1H-indol-2-yl)-1-methyl-1H-imidazo[4,5-c]pyridin-2-yl]pyridin-1-ium (non-preferred name), NAD(+) hydrolase SARM1 Authors: Dementiev, A, Olland, A.M, Johnson, Z.L. Deposit date: 2026-02-02 Release date: 2026-04-22 Last modified: 2026-04-29 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure-Based Discovery of Imidazo[4,5- c ]pyridine SARM1 Modulators Showing Paradoxical Activation. J.Med.Chem., 69, 2026
创建时间：
2026-02-02
