Recruitment of ABLIM to the plasma membrane

Unc-115/AbLIM is a key regulator of lamellipodia and filopodia in the growth cone during axon pathfinding and acts downstream of Rac GTPase signaling. It acts as a scaffold to recruit other actin-modulating complexes involved in lamellipodia and filopodia. Unc-115/AbLIM is locally recruited to the plasma membrane by activated Rac1 and subsequently dephosphorylated on serine 617. Dephosphorylated Unc-115/AbLIM then might interact with other molecules at the plasma membrane to induce formation of lamellipodia and filopodia by reorganization of the actin cytoskeleton.

Unc-115/AbLIM作为轴突寻路过程中生长锥中板层伪足和丝状伪足的关键调控因子，位于Rac GTPase信号通路下游。它充当支架以募集参与板层伪足和丝状伪足形成的其他肌动蛋白调节复合物。活化后的Rac1将Unc-115/AbLIM局部募集至质膜，随后在丝氨酸617位发生去磷酸化。去磷酸化的Unc-115/AbLIM随后可能与质膜上的其他分子相互作用，通过肌动蛋白细胞骨架的重排诱导板层伪足和丝状伪足的形成。