Data from: A simple biophysical model emulates budding yeast chromosome condensation

Mitotic chromosomes were one of the first cell biological structures to be
described, yet their molecular architecture remains poorly understood. We
have devised a simple biophysical model of a 300 kb-long nucleosome chain,
the size of a budding yeast chromosome, constrained by interactions
between binding sites of the chromosomal condensin complex, a key
component of interphase and mitotic chromosomes. Comparisons of
computational and experimental (4C) interaction maps, and other
biophysical features, allow us to predict a mode of condensin action.
Stochastic condensin-mediated pairwise interactions along the nucleosome
chain generate native-like chromosome features and recapitulate chromosome
compaction and individualization during mitotic condensation. Higher order
interactions between condensin binding sites explain the data less well.
Our results suggest that basic assumptions about chromatin behavior go a
long way to explain chromosome architecture and are able to generate a
molecular model of what the inside of a chromosome is likely to look like.