Supplementary Material for: Quadrant‑Based Comparison of UV‑Fluorescence Dermoscopy, Standard Dermoscopy, and Clinical Examination in Adults With Nail Psoriasis: A Prospective Pilot Study of 35 Patients

Background: Accurate visualization of nail‐matrix psoriasis remains challenging. Ultraviolet fluorescence dermoscopy (UVF D) may enhance detection, yet rigorous comparative data are scarce.
Objectives: To compare the diagnostic yield of UVF D with standard dermoscopy and naked eye clinical examination for matrix and bed involvement in nail psoriasis.
Methods: In this single center prospective pilot study (March–July 2024), 35 consecutive adults with plaque psoriasis underwent triplicate assessment (clinical, dermoscopy, UVF D) of all fingernails. Each nail quadrant was scored for matrix NAPSI and bed NAPSI by two blinded dermatologists in randomized order. The study was powered (80 %, α = 0.05) to detect a ≥ 3 point mean difference in matrix NAPSI between modalities.
Results: UVF-D identified matrix involvement in 550/1 400 quadrants (39.3 %) versus 448/1 400 (32.0 %) with standard dermoscopy and 441/1 400 (31.5 %) clinically (p < 0.001; Kendall’s W = 0.42). Mean ± SD matrix-NAPSI scores were 15.7 ± 5.3 (UVF-D), 12.8 ± 5.2 (dermoscopy) and 12.6 ± 4.8 (clinical). Thus, UVF-D detected roughly one additional matrix-affected quadrant for every seven examined and produced a higher matrix-NAPSI, underscoring its added sensitivity over conventional methods.
Limitations: Single-centre pilot (n = 35); consensus scoring precluded formal inter-observer reliability estimates; cross-sectional design prevents evaluation of treatment responsiveness; UVF-D hardware cost and user-training requirements may restrict generalisability.
Conclusions: UVF D significantly improves visualization of nail matrix psoriasis versus standard approaches. Larger multicenter studies should validate its diagnostic and longitudinal utility.