Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

In addition, following a homeostatic downscaling of neuronal activity many circRNAs exhibit significant up or down-regulation. These data indicate that brain circRNAs are positioned to respond to and regulate synaptic function.此外，在神经元活动发生稳态下调后，大量环状RNA（circRNAs）会出现显著的上调或下调表达。上述数据表明，脑内环状RNA能够响应并调控突触功能。