PRMT5 regulates the homologous recombination DNA repair pathway by controlling the alternative splicing of key epigenetic factors
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
We found that PRMT5 deletion or inhibition impairs homologous recombination (HR) DNA repair, leading to DNA damage accumulation, p53 activation, cell cycle arrest and cell death through missplicing of KAT5.We show that PRMT5 inhibitors and PARP inhibitors have synergistic effects on human acute leukemia cell lines, demonstrating the advantages of combining targeted epigenetic and non-epigenetic inhibitors.
提供机构：
University of Miami
创建时间：
2022-02-20
