High Throughput Chromosome Conformation Capture identifies differential genome organization in virulent and avirulent strains of Mycobacterium tuberculosis

In order to understand the three-dimensional genome organization in M. tuberculosis, in this study we have used exponentially growing mycobacterial culture. We performed Hi-C on both virulent and attenuated strain of M. tuberculosis and analyzed data by using Hi-C explorer tools Overall design: Comparative chromosome oganization in Mycobacterium tuberculosis strain H37Rv and H37Ra using Hi-C