Additional file 2 of Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology

Additional file 2: Table S1. Master Table of clinicopathological characteristics of 3,115 patients with NSCLC sequenced at DFCI. Table S2. EGFRL858R/ex19del/ex20ins variants reported in patients with NSCLC sequenced at DFCI. Table S3. KRASG12C variants reported in patients with NSCLC sequenced at DFCI. Table S4. Exon 14 skipping mutations and/or amplifications in MET reported in patients with NSCLC sequenced at DFCI. Table S5. ALK fusions reported in patients with NSCLC sequenced at DFCI. Table S6. ROS1 fusions reported in patients with NSCLC sequenced at DFCI. Table S7. BRAFV600E variants reported in patients with NSCLC sequenced at DFCI. Table S8. RET fusions reported in patients with NSCLC sequenced at DFCI. Table S9. NTRK fusions reported in patients with NSCLC sequenced at DFCI. Table S10. Master Table of clinicopathological characteristics of 5,560 patients with NSCLC sequenced at one of three institutions (DCC, VICC, MSKCC). Table S11. Frequency of eight targetable alterations in DFCI LUAD patients by pack-year groups. Table S12. Comparison of targetable alteration frequencies in pack-year groups among patients with NSCLC at DFCI. Table S13. Distribution of targetable alterations by pack-year smoking history among patients with LUSC at DFCI. Table S14. Multivariable logistic regression model of eight targetable alterations, incorporating continental ancestry scores, age at diagnosis, smoking pack-year history, sex and histology DFCI cohort). Table S15. Comparison of KRASG12C mutation frequencies across continental ancestries (discovery cohort from DFCI) and self-reported racial groups (validation cohort from DCC, MSKCC, and VICC). Table S16. Multivariable logistic regression model of eight targetable alterations, incorporating sex and histology (validation cohort). Table S17. Tumor mutational burden and Ashkenazi Jewish ancestry assessment in TCGA LUAD and LUSC cohorts. Table S18. Multivariable logistic regression model of eight targetable alterations, incorporating Ashkenazi Jewish ancestry scores, age at diagnosis, smoking pack-year history, sex and histology.