Relative replicative fitness, relative infectivity, and pre-existing frequencies of various mutants.
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Replicative fitness was estimated by analyzing competitive growth assays where available (S1 Fig) and by assuming zero epistasis otherwise. For the N279K and N280D mutants, competitive growth assays indicated replicative fitness indistinguishable from the wild-type. The relative infectivity of each strain was calculated as the ratio of its % infectivity to that of the wild type, reported elsewhere [28]. The frequencies were obtained using our model (Eqs (1)–(10)). (XLSX)
创建时间：
2020-11-30
