Spatial component of: CELSR3 deficiency leads to tic-related behaviors and dopaminergic alterations in the striatum

The gene CELSR3 (cadherin EGF LAG seven-pass-G-type receptor 3) has been recently recognized as a high-confidence risk factor for tic disorders (TD). Celsr3 mutant mice displayed tic-like grooming stereotypies and jerks, as well as sensorimotor gating deficits, which were opposed by TD therapies. Spatial transcriptomic analyses revealed that Celsr3 mutants featured abnormalities of the extracellular matrix in the striatum. Notably, there are alterations in collagen and extracellular organization. Overall design: Coronal sections from 4 distinct mice ( 2 from each group: Celsr3 WT and HZ) from FFPE preserved samples were analyzed by Visium Cytassist