Small-molecule Allosteric Regulation Mechanism of SHP2

Small-molecule Allosteric Regulation Mechanism of SHP2 Descriptor: 2-[(3S,4R)-4-azanyl-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-[2,3-bis(chloranyl)phenyl]-3-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-one, Tyrosine-protein phosphatase non-receptor type 11 Authors: Luo, Y, Zhu, J, Yu, K, Liu, B. Deposit date: 2022-04-09 Release date: 2023-02-15 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one. J Enzyme Inhib Med Chem, 38, 2023