Enrichment of non-polymorphic sites with respect to stability evaluated in different structures.

The p-values of enrichment analysis (column 3, also see Fig 3B) of non-polymorphic residues among sites contributing most to protein stability using different pdb structures (column 2) of MHC-I alleles (column 1) is shown below. For each pdb structure, we merged the peptide and the MHC-I allele on the same chain and ran AlaScan to measure the stability scores.