Copanlisib modulates HAIR-M transcriptome

Exposure to copanlisib in an MZL cell line heavily affected the lymphoma cell transcriptome, downregulating the MYC transcriptional program, alongside NFkB signaling, mTOR signaling, glycolysis, genes that are essential for cancer cells and also molecules important for immune escape (CD274, PDCD1, CSF1, TIMP1), suggesting the exploration of combinations including copanlisib and immune-checkpoint modulators. Overall design: To assess the effects of copanlisib on the transcriptome, we exposed the MZL cell line HAIR-M to DMSO or copanlisib (5nM, for 4, 8 and 12 h) in triplicates.