Integration of toxicological end points with molecular measurements in a 28-day rat repeated dose inhalation study with cigarette smoke provides mechanistic understanding of smoke impact

In conclusion, a correlative evaluation of classical histopathology together with gene expression?based computational network models may facilitate a systems toxicology-based risk assessment as shown for a pMRTP.综上所述，针对经典组织病理学与基于基因表达的计算网络模型开展关联评估，可助力基于系统毒理学的风险评估，正如一项针对pMRTP的研究所呈现的那样。