Role of Matrix Gla Protein in Brown Adipose Tissue Development

To investigate matrix gla protein (Mgp) function in angiogenesis and adipogenesis in brown adipose tissue (BAT) of C57BL/6 mice. we dissected 5 pairs of BAT from 4 weeks male Mgp wild-type (WT) and knock out (KO) mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of 5 pairs of WT and KO mice. Comparative gene expression profiling between Mgp KO and WT mice in brown adipose tissue .为探究基质γ-羧基谷氨酸蛋白（matrix gla protein, Mgp）在C57BL/6小鼠棕色脂肪组织（brown adipose tissue, BAT）的血管生成与脂肪生成中的功能，我们从4周龄雄性Mgp野生型（wild-type, WT）与基因敲除（knock out, KO）小鼠体内解剖获取了5对棕色脂肪组织样本。随后基于5对WT与KO小鼠的RNA测序（RNA-seq）数据开展基因表达谱分析，对比Mgp KO与WT小鼠棕色脂肪组织的基因表达谱差异。