Pou3f4
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=62240
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资源简介：
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cochlea morphogenesis and negative regulation of mesenchymal cell apoptotic process. Acts upstream of or within forebrain neuron differentiation; inner ear development; and sensory perception of sound. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; cranium; ear; embryo ectoderm; and foregut-midgut junction. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to human POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Nov 2024]
赋予 RNA 聚合酶 II 转录调控区序列特异性 DNA 结合活性。参与耳蜗形态发生及间充质细胞凋亡过程的负向调控。在端脑神经元分化、内耳发育和声音感知的感官知觉过程中发挥上游或内部作用；预测其定位于核质内。在多个结构中表达，包括大脑、颅骨、耳、胚胎外胚层以及前肠-中肠连接处。此基因的人类同源基因与 X 连锁性听力损失 2 相关。与人 POU3F4（POU 类 3 同源框 4）同源。[由基因组资源联盟提供，2024 年 11 月]
提供机构：
Rat Genome Database
