Development of gene expression signatures for barrier recovery phase in epidermis from acute barrier disruption

The skin barrier consists of multiple lipid-enriched layers. Sodium lauryl sulfate is a well-known substance that can disrupt the skin barrier. The mechanisms underlying the barrier repair process, especially the influence of topical sodium lauryl sulfate treatment in the barrier recovery phase remain unresolved. To understand the process of reconstruction of the intercellular lipid layer of the skin after acute barrier disruption by sodium lauryl sulfate treatment in vivo. Female hairless mice were treated with 3% sodium lauryl sulfate. Gene expression analysis were performed from 1 to 288 h after the topical application of 3% sodium lauryl sulfate.