Clinical and histopathological characteristics.

1,078 patients (561 male and 517 female) diagnosed from 1976 to 2008 as invasive primary cutaneous melanoma who developed metastases during follow up stratified by sex and metastatic pathway.The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study.ALM, acral lentiginous melanoma; IQR, interquartile range; LMM, lentigo maligna melanoma; NM, nodular melanoma; NS, not significant; SSM, superficially spreading melanoma.Pathway 1, primary tumor, then satellite/in-transit metastases; Pathway 2, primary tumor, then regional lymph node metastasis; Pathway 3, primary tumor, then distant metastasis.*Pearson's χ2 test.†Mann-Whitney test.