Crystal structure of HIV-1 protease with GS-9770

Crystal structure of HIV-1 protease with GS-9770 Descriptor: (2S)-2-{(3M)-4-chloro-3-[1-(difluoromethyl)-1H-1,2,4-triazol-5-yl]phenyl}-2-[(2E,4R)-4-[4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)phenyl]-2-imino-5-oxo-4-(3,3,3-trifluoro-2,2-dimethylpropyl)imidazolidin-1-yl]ethyl [1-(difluoromethyl)cyclopropyl]carbamate, HIV-1 protease Authors: Lansdon, E.B. Deposit date: 2023-12-11 Release date: 2024-03-06 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob.Agents Chemother., 68, 2024