Datasets and metadata supporting the published article: BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression

<b>Summary:</b>The datasets described here were gathered while investigating the molecular processes by which some human ductal carcinoma in situ (DCIS) lesions advance to the more aggressive form while others remain indolent.<br><b>Data access:</b>All RNA sequencing data have been deposited in the <i>Gene Expression Omnibus</i> with accession https://identifiers.org/geo:GSE143790 All Chip-Exo data have been deposited in the <i>Gene Expression Omnibus</i> with accession https://identifiers.org/geo:GSE143313 RPPA data is included together with this data record, in the file <b>Supplementary Figure 3-RPPA.xlsx</b>. The Raw RPPA and ANOVA tabs are the results, while the other tabs are IPA analysis performed by the authors. Permission to use figures and data generated using QIAGEN Ingenuity Pathway Analysis (IPA) is given in the file <b>QIAGEN Ingenuity Product Support Permission letter for Dr. Behbod.pdf</b>.The specific data underlying each figure and supplementary figure in the manuscript are provided as part of this data record, and are as follows:<b>Figure 1-BCL9-STAT3 interaction.xlsx</b><b>Figure 2-ChIP Exo.xlsx</b><b>Figure 3-ChIP.xlsx</b><b>Figure 4-MMP16 and avb3 MIND xenografts.xlsx</b><b>Figure 5-MMP16 avb3 TMA analysis.xlsx</b><b>Figure 6-Carnosic data.xlsx</b><b>Supplementary Figure 3-RPPA.xlsx</b><b>Supplementary Figure 4-STAT3 Reporter.xlsx</b><b>Supplementary Figure 5-ChIP Exo Motifs.xlsx</b><b>Supplementary Figure 6-integrin data.xlsx</b><b>Supplementary Figure 7-MMP data.xlsx</b><br><b>Study approval and patient consent: </b>Patients gave written informed consent for participation in the University of Kansas Medical Center Institutional Review Board–approved study allowing collection of additional biopsies and or surgical tissue for research. Animal experiments were conducted following protocols approved by the University of Kansas School of Medicine Animal Care and Use and Human Subjects Committee. <b><br></b><b>Study aims and methodology: </b>The aim of the related study was to determine the molecular processes underlying progression to invasion in DCIS using PDX DCIS MIND animal models. Using a novel intraductal model they identify downregulation of specific STAT3 targets to promote progression and use a purified component from rosemary extract to show that treatment <i>in vivo</i> decreases DCIS progression in patient derived DCIS and cell line models.<br>