RNA sequencing and analysis of human eosinophils stimulated with C3a and C5a

Activated eosinophils is a major cell type to be involved in allergic diseases. Complement molecules (C3a and C5a) are important to establish and augment its inflammatory process. IL-5 primarily activates eosinophils and prolongs their survival. However, the direct effects of C3a and C5a on human eosinophils remains fully uncovered. The aim of this study is to clarify the role of these mediators as direct activators for human eosinophils.