Crystal Structure of Human Beta Secretase in Complex with NVP-BQQ711
收藏Protein Data Bank Japan2024-11-27 更新2026-03-21 收录
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Crystal Structure of Human Beta Secretase in Complex with NVP-BQQ711 Descriptor: (3S,4S,5R)-3-(4-amino-3-bromo-5-fluorobenzyl)-5-{[3-(1,1-difluoroethyl)benzyl]amino}tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1 Authors: Rondeau, J.M, Bourgier, E. Deposit date: 2012-01-09 Release date: 2012-11-21 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides J.Med.Chem., 55, 2012
创建时间：
2012-01-09
