Table_1_The impact of hyperglycaemic crisis episodes on long-term outcomes for inpatients presenting with acute organ injury: A prospective, multicentre follow-up study.docx

BackgroundThe long-term clinical outcome of poor prognosis in patients with diabetic hyperglycaemic crisis episodes (HCE) remains unknown, which may be related to acute organ injury (AOI) and its continuous damage after hospital discharge. This study aimed to observe the clinical differences and relevant risk factors in HCE with or without AOI.MethodsA total of 339 inpatients were divided into an AOI group (n=69) and a non-AOI group (n=270), and their differences and risk factors were explored. The differences in clinical outcomes and prediction models for evaluating the long-term adverse events after hospital discharge were established.ResultsThe mortality among cases complicated by AOI was significantly higher than that among patients without AOI [8 (11.59%) vs. 11 (4.07%), Q = 0.034] during hospitalization. After a 2-year follow-up, the mortality was also significantly higher in patients with concomitant AOI than in patients without AOI after hospital discharge during follow-up [13 (21.31%) vs. 15 (5.8%), Q < 0.001]. The long-term adverse events in patients with concomitant AOI were significantly higher than those in patients without AOI during follow-up [15 (24.59%) vs. 31 (11.97%), Q = 0.015]. Furthermore, Blood β-hydroxybutyric acid (P = 0.003), Cystatin C (P

背景：糖尿病高血糖危象（HCE）患者预后不良的长期临床结果尚不明确，此结果可能与急性器官损伤（AOI）及其出院后的持续损伤有关。本研究旨在观察伴有或未伴有AOI的HCE患者的临床差异及相关风险因素。方法：共纳入339名住院患者，分为AOI组（n=69）和非AOI组（n=270），并探讨其差异和风险因素。建立了评估出院后长期不良事件的临床结果和预测模型。结果：住院期间，合并AOI的病例死亡率显著高于无AOI的患者[8例（11.59%）比11例（4.07%），Q=0.034]。随访2年后，出院后随访期间合并AOI的患者死亡率也显著高于无AOI的患者[13例（21.31%）比15例（5.8%），Q<0.001]。随访期间，合并AOI的患者长期不良事件发生率显著高于无AOI的患者[15例（24.59%）比31例（11.97%），Q=0.015]。此外，血液β-羟基丁酸（P=0.003）、半胱氨酸蛋白酶C（P