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Antigen experience history directs distinct functional states of CD8+ CAR T cells during the anti-leukemia response

NIAID Data Ecosystem2026-05-02 收录

CAR-T细胞疗法

白血病免疫治疗

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249734 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-02-10

CAR-T细胞疗法

免疫信号通路

RNAseq analysis of human CAR-Tregs, bearing CD28 or 4-1BB as a costimulatory domains, initially isolated (before engineering) from peripheral blood of healthy donors Overall design: CD25+ naive Tregs

NIAID Data Ecosystem100

mRNA expression profile of Lymphocytes by high-throuput sequencing. Homo sapiens

白血病免疫治疗

T细胞编程

The activation of CD4+ T helper (Th) cells is crucial for the induction of cytotoxic T lymphocyte (CTL) responses against malignancy. We reprogrammed a Th clone specific for chronic myelogenous leukem

NIAID Data Ecosystem30

Patient data from ELISPOT assay from [8] for P1, P4, and P12.

白血病免疫治疗

ELISPOT检测

SFCs/well for leukemia bearing+remission PBMCs. The measurement for time 0 corresponds to pre-treatment leukemia bearing PBMCs. (See Figure 2 for plots of the data points.)

NIAID Data Ecosystem30

Gallic acid enhances increases the graft-versus-leukemia effects of T cells without exacerbating graft-versus-host disease after hematopoietic stem cell transplantation

白血病免疫治疗

移植物抗宿主病免疫调节

Gallic acid enhances increases the graft-versus-leukemia effects of T cells without exacerbating graft-versus-host disease after hematopoietic stem cell transplantation

integrated proteome resources60

De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release

CAR-T细胞疗法

跨膜结构域

De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release

NIAID Data Ecosystem30